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butabarbital will lessen the level or effect of doxorubicin liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.butabarbital will lower the level or influence of estrogens esterified by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.butabarbital will decrease the extent or in